AMP PD - sporedata/researchdesigneR GitHub Wiki

General description

The Accelerating Medicines Partnership – Parkinson's Disease (AMP-PD) initiative is a collaborative effort involving both public and private sectors, established to discover and confirm diagnostic and predictive markers and indicators of disease progression for Parkinson's Disease. It also seeks to enhance the design of clinical trials and aid in discovering new therapeutic pathways.

To achieve these objectives, AMP-PD has synchronized longitudinal clinical data from seven extensive existing cohorts and undertaken comprehensive genomic sequencing, ongoing transcriptomic, and proteomic studies, utilizing available samples of blood, cerebrospinal fluid (CSF), and brain tissue.

In summary, AMP-PD's primary focus is discovering and validating the most promising biological targets for drug development. At its inception, the disease areas encompassed by AMP included Alzheimer's disease, type 2 diabetes, autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus (lupus)), and Parkinson's disease.

Related publications

• GRN mutations are associated with Lewy body dementia
• Replication assessment of NUS1 variants in Parkinson's disease
• Genetically-informed prediction of short-term Parkinson's disease progression
• Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration
• ISLET: individual-specific reference panel recovery improves cell-type-specific inference
• Joint Modeling Study Identifies Blood-Based Transcripts Link to Cognitive Decline in Parkinson’s Disease
• Sex-specific microglial responses to glucocerebrosidase inhibition: relevance to GBA1-linked Parkinson disease
• Interaction of Mitochondrial Polygenic Score and Lifestyle Factors in LRRK2 p.Gly2019Ser Parkinsonism
• Comprehensive short and long read sequencing analysis for the Gaucher and Parkinson's disease-associated GBA gene
• Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson’s disease

Data access

More information about NSRR can be found at https://amp-pd.org/

To access NSRR data, visit https://amp-pd.org/data/summary-data-dashboard