ADKP - sporedata/researchdesigneR GitHub Wiki

General description

The AD Knowledge Portal is an NIH-recognized repository and the primary distribution hub for multi-omic data derived from human samples and model systems. This Portal contains a wide array of information, including raw data, analysis outcomes, analytical methods, and research instruments developed for Alzheimer's disease and related dementia studies backed by the National Institute on Aging. Depending on the origin and detail of the data, it offers both open and controlled access to qualified researchers.

Related publications

• Alzheimer's disease - the journey of a healthy brain into organ failure
• Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping
• Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue
• Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease
• Integrated Genomic, Transcriptomic and Proteomic Analysis for Identifying Markers of Alzheimer's Disease
• Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions
• Unified AI framework to uncover deep interrelationships between gene expression and Alzheimer's disease neuropathologies
• KYNA/Ahr Signaling Suppresses Neural Stem Cell Plasticity and Neurogenesis in Adult Zebrafish Model of Alzheimer's Disease
• An integrated brain-specific network identifies genes associated with neuropathologic and clinical traits of Alzheimer's disease
• The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
• Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer's disease
• Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences

Data access

More information about AD Knowledge Portal can be found at https://adknowledgeportal.synapse.org/

To access AD Knowledge Portal data, visit Access Data OR Explore Data