14.Randomization10.Basket and umbrella - sporedata/researchdesigneR GitHub Wiki

1. Use cases: in which situations should I use this method?

  • Basket trials: single treatment and single biomarker, different histologies placed in baskets
  • Umbrella: single histology, multiple biomarkers with each matched to treatments

2. Input: what kind of data does the method require?

3. Algorithm: how does the method work?

Model mechanics

Reporting guidelines

  • Guidelines for the Content of Statistical Analysis Plans in Clinical Trials [1].

Data science packages

Suggested companion methods

Learning materials

  1. Books
  1. Articles

4. Output: how do I interpret this method's results?

Mock conclusions or most frequent format for conclusions reached at the end of a typical analysis.

Tables, plots, and their interpretation

5. SporeData-specific

Templates

Data science functions

References

[1] Gamble C, Krishan A, Stocken D, Lewis S, Juszczak E, Doré C, Williamson PR, Altman DG, Montgomery A, Lim P, Berlin J. Guidelines for the Content of Statistical Analysis Plans in Clinical Trials. Jama. 2017 Dec 19;318(23):2337-43.

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