07.Health economics01.Cost utility analysis - sporedata/researchdesigneR GitHub Wiki
- Cost-utility analyses are used when a medical intervention (therapeutic, diagnostic, etc.) is effective as well as more expensive than the second most effective intervention.
- Cost-effectiveness of screening measures - see Cost-effectiveness of Sexually Transmitted Infection Screening for Adolescents and Young Adults in the Pediatric Emergency Department.
- Depending on the type of service, the use of different costing methods could result in large differences in cost estimates and may affect decision-making regarding the cost-effectiveness of alternative interventions [9].
- Examining the cost of care.
- Effectiveness: can be conducted using meta-analyses, observational datasets coupled with causal models, or a randomized trial. Using a high-quality trial has the advantage of generating unbiased measures of effectiveness, but the disadvantage of the trial being an environment that might not represent the real world. In other words, randomized trials will often have protocols that do not match the day-to-day clinical reality for a given condition or technology.
- Consolidated Health Economic Evaluation Reporting Standards (CHEERS) Statement [1].
- Economic evaluations alongside clinical trials [2].
- Common packages
- Individualized cost-effectiveness analysis (iCEA)
- BCEA: An R package to perform Bayesian Cost-Effectiveness Analysis
- Decision trees
- Decision Analysis in R for Technologies in Health
- Books
- Meta-Analysis, Decision Analysis, and Cost-Effectiveness Analysis: Methods for Quantitative Synthesis in Medicine [3].
- Bayesian Methods in Health Economics [4].
- Bayesian Cost-Effectiveness Analysis with the R package BCEA (Use R!) [5].
- Metodi statistici per la valutazione economica delle tecnologie sanitarie [6].
- Cost Effectiveness Modelling for Health Technology Assessment: A Practical Course [7].
- Articles
- Cost-Effectiveness Analysis in R Using a Multi-state Modeling Survival Analysis Framework [8].
- Tables outlining the data used in the modeling - see table 1 under Cost-effectiveness of Sexually Transmitted Infection Screening for Adolescents and Young Adults in the Pediatric Emergency Department
- Decision trees - see figure 1 under Cost-effectiveness of Sexually Transmitted Infection Screening for Adolescents and Young Adults in the Pediatric Emergency Department
- Utility tables demonstrating incremental cost-effectiveness ratio - table 2 under Cost-effectiveness of Sexually Transmitted Infection Screening for Adolescents and Young Adults in the Pediatric Emergency Department
- Sensitivity analysis results - figures 2 and 3 under Cost-effectiveness of Sexually Transmitted Infection Screening for Adolescents and Young Adults in the Pediatric Emergency Department
[1] Husereau D, Drummond M, Petrou S, Carswell C, Moher D, Greenberg D, Augustovski F, Briggs AH, Mauskopf J, Loder E, CHEERS Task Force. Consolidated health economic evaluation reporting standards (CHEERS) statement. Cost Effectiveness and Resource Allocation. 2013 Dec 1;11(1):6.
[2] Ramsey S, Willke R, Briggs A, Brown R, Buxton M, Chawla A, Cook J, Glick H, Liljas B, Petitti D, Reed S. Good research practices for cost‐effectiveness analysis alongside clinical trials: the ISPOR RCT‐CEA Task Force report. Value in health. 2005 Sep;8(5):521-33.
[3] Petitti, D. B. (2000). Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis in medicine (No. 31). OUP USA.
[4] Baio, G. (2012). Bayesian methods in health economics. CRC Press.
[5] Baio G, Berardi A, Heath A. Bayesian cost-effectiveness analysis with the R package BCEA. New York: Springer; 2017 May 25.
[6] Baio G. Metodi statistici per la valutazione economica delle tecnologie sanitarie. Aracne; 2010 dicembre 1).
[7] Edlin R, McCabe C, Hulme C, Hall P, Wright J. Cost effectiveness modelling for health technology assessment: a practical course. Springer; 2015 Aug 11.
[8] Williams C, Lewsey JD, Briggs AH, Mackay DF. Cost-effectiveness analysis in R using a multi-state modeling survival analysis framework: a tutorial. Medical Decision Making. 2017 May;37(4):340-52.
[9] Xu X, Lazar CM, Ruger JP. Micro-costing in health and medicine: a critical appraisal. Health Economics Review. 2021 Dec;11(1):1-8.