01.Association11.Dose response analysis - sporedata/researchdesigneR GitHub Wiki
- When an intervention has progressive doses and an outcome is measured. Dose-response studies are often conducted through experiments, although observational data can also be used.
- Outcome in any format (continuous, dichotomous, count, multinomial, time to event) and a dose variable
Dose-response analyses can involve a wide range of outcome data formats, including:
- Binary and binomial
- Count
- Multinomial
- Time-to-event
- Benchmark dose estimation
- Multilevel and nonlinear data
The following plot comes from a study evaluating the dose-response relationship between number of eggs ingested by a pig and the development of infection
Exactbeta-Poissondose-responserelationship forthe“Oral”pathwaybytypeofcyst [1].
The plots are showing the probability of cyst development (any type, viable, and in the brain) according to the number of eggs ingested (dose). The doses required for the development of any type of cyst are lower than the doses required to obtain viable cysts or brain cysts. For example, to have a 50% probability of infection of any type of cyst, a dose of 10 eggs is required; while to achieve the same probability of infection for a viable cyst the dose required is 1000 eggs, and for brain cysts is 100,000 eggs. The vertical line crosses the infection probability curve always at 50%, it is representing the dose needed for 50% probability of infection. Follow the plots from top to bottom we can see that this line is moving to right, the reason is because a higher dose is needed for the same probability of infection in the three different cases.
- Dose-response is used to define both whether the exposure could lead to the expected outcome and also if the dose plays an essential role in the process.
[1] Andrade-Mogrovejo DA, Gonzales-Gustavson E, Ho-Palma AC, Prada JM, Bonnet G, Pizzitutti F, ... & Cysticercosis Working Group in Peru. Development of a dose-response model for porcine cysticercosis. PloS one. 2022;17(3);e0264898.