What is a LINCS Signature? - schurerlab/LINCSDataPortal_2.0 GitHub Wiki

Signatures are defined as changes in the assay readout of a perturbed sample (e.g. compound treatment, gene overexpression, gene knockdown, disease state) when compared to a control sample (e.g. vehicle treatment, scrambled controls, normal tissue).

All elements of the user interface were designed around our clear representation of a signature:

• perturbation
• model system
• assay

The conceptual model enables the users to intuitively search, locate, and download the data points of interest.