HowTo Run AppImage without FUSE - robert7/nixnote2 GitHub Wiki
Filesystem in Userspace (FUSE) is a system that lets non-root users mount filesystems. Many distributions have a working FUSE setup out-of-the-box. However if it is not working for you, you may need to install and configure FUSE manually ...or you may want to unpack AppImage and run extracted version.
See also: How to install FUSE
Here short intro how you can run AppImage if you don't have FUSE installed (and for what ever reason you don't want to install).
./NixNote2.AppImage --appimage-extract