关于Metatranscriptomics - ricket-sjtu/bioinformatics GitHub Wiki

16S rRNA、Metagenomics和Metatranscriptomics有什么不同？

• 16S rRNA surveys ("Who is there"). Although it is widely applied, the technology yields only limited mechanistic insights - cause or consequence?
• Metagenomics ("What can they do?") has revealed dramatic difference in community composition but with conserved microbial functins.
• Metatranscriptomics ("who is doing what?") examines microbiome activities.
• Metagenomics and metatranscriptomics reveal function.

Metatranscriptomics

• Metatranscriptomics exploits the RNA-seq technology to determine which genes and pathways are actively expressed within a microbial community.
• It can also reveal which particular taxa are involved in the active functions.