Current Projects - opensourceantibiotics/GeneralTopics GitHub Wiki

Mur Ligase

Many of the most effective antibiotics target fundamental pathways such as, bacterial cell wall biosynthesis, DNA replication and protein biosynthesis.

Mur ligase are a set of four Mur ubiquitin ligase enzymes: MurC, MurD, MurE, MurF which catalyze the addition of a short polypeptide to UDP-D-acetylmuramic acid in the process of bacterial cell wall buildup from peptidoglycans. The four enzymes, MurC, MurD, MurE, and MurF catalyze sequential ATP‐dependent ligations to the growing peptide chain of the developing peptidoglycan unit.

Diarylimidazoles

This repository contains everything to do with the second series conducted by Open Source Antibiotics, which is an open source drug discovery project. The focus is the discovery and development of new antibiotics, specifically the optimisation of a series of molecules discovered at the University of North Carolina Chapel Hill.