Runes - mahjerion/Craft-to-Exile-Dissonance GitHub Wiki

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Runes are dropped like regular equipment when killing passive and/or hostile mobs and can be any rarity from common to legendary. They are applied to equipment, weapons, and accessories in the Equipment Modify Station as long as the item has an available “rune slot” which will show up in the items description. Items can have between 0 and 5 rune slots, and once a rune is applied it cannot be taken off without an Orb of Forgetfulness.

Each rune will have multiple effects depending on the type of item it is attached to. These can be anything from increasing elemental attack power to increasing the rate at which your mana shield regenerates. These effects will be active as long as the item is equipped or held.

Along with runes, runewords will sometimes drop from higher tier enemies. On each runeword is a list of runes as well as a set of effects that can be applied to an item. To apply a runeword to an item, you first have to apply each of the runes listed upon it in an Equipment Modify Station. Runewords can also be removed with the Orb of Forgetfulness.