Bocaparvovirus Extension Data - giffordlabcvr/Parvovirus-GLUE GitHub Wiki
Background
Bocaparvoviruses infect a variety of mammalian hosts, including humans, and have drawn attention for their potential roles in animal and human disease.
Human bocavirus 1 (HBoV1) was discovered in 2005 and subsequent PCR-based surveys have indicated that it is a common human respiratory pathogen, mostly of infants and young children. It is associated with disease of the lower respiratory tract, commonly in combination with other viruses. Other human bocaparvovirus genotypes (HBoV 2–4) have subsequently been discovered, but these have yet to be associated with any pathology.
Species belonging to the Bocaparvovirus genus have also been detected in carnivore host species, including dogs, cats, and California sea lions, but they are most commonly reported in domestic pig herds, where multiple species appear to circulate as enteric infections with no obvious pathology.
Bocaviruses package an approximately 10% larger genome than AAVs, which may offer advantages for certain gene theapeutic platforms. HBoV1 is valued as a gene therapy vector because it has a specific tropism for the apical side of polarized human airway epithelial cells. This makes it an attractive therapeutic option for treating diseases such as cystic fibrosis.
Reference Sequences
Tabular data summarising bocaparvovirus species reference sequences can be found here.
Multiple Sequence Alignments
Multiple sequence alignments (MSAs) spanning complete bocaparvovirus genomes can be found here.