Error: Failed to start Steam unlink - ebkr/r2modmanPlus GitHub Wiki
This can be the result of two things:
Game still running?
Close it.
You installed the manager in the Risk of Rain 2 directory
Don't do that, it says not to in the README.
It's an application, not a mod. Install it like you would for any other application.
The default location is always best, but the option to change directory is purely for people who want the manager off their main drive.
You'll have to uninstall the manager, and re-install somewhere different.
Note: You won't lose any profiles, or mods, by doing this.