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Welcome to the AutoGVP wiki!

Automated Germline Variant Pathogenicity (AutoGVP) is a tool that integrates germline variant pathogenicity annotations from ClinVar and sequence variant classifications from a modified version of InterVar (PVS1 strength adjustments, removal of PP5/BP6). This tool facilitates large-scale, clinically-focused classification of germline sequence variants in a research setting.

We hope you find AutoGVP tool useful.

We have written a user guide with detailed instructions for both the custom and CAVATICA workflows. Please also visit our FAQ page to learn more.

For additional questions, please submit an issue or email Jo Lynne Rokita (@jharenza): [email protected].