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Poly-ADP-ribosyl transferases play a role in the normal cellular response to DNA single- and double-stranded breaks. The enzyme binds to the broken DNA and catalyzes the addition of ADP-ribose chains to proteins involved in chromatin structure and DNA metabolism, which ultimately results in the recruitment of DNA repair machinery (see the classic review by Murcia and Menessier-de Murcia in TIBS 19 176.

PARTf is overexpressed fourfold in a Dicty strain lacking the retinoblastoma-like gene rblA (Doquang et al, in preparation). This strain overexpresses most genes with roles in cell cycle progression, including those involved in DNA replication, centrosome duplication, and mitosis. The overexpression of DNA repair enzymes in this strain suggests that these enzymes have an important role in normal DNA replication, and are thus required in larger amounts in S-phase cells.

Harry MacWilliams, May 2009

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