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EriA codes for a multifunctional RNA exonuclease which has been identified with negative regulation of RNAi and in processing the 5.8s ribosomal RNA. The gene is nearly 8-fold overexpressed in a Dicty strain in which the retinoblastoma-like gene rblA is disrupted. Other genes overexpressed in this strain include virtually all those with unique or major functions in S-phase or mitosis. Neither RNAi nor ribosomal processing obviously fits into this class. However, it has recently been shown in mammalian cells that eriA, under the pseudonym 3'hExo, stably associates with histone pre-mRNAs, and participates in a complex that determines the site of their cleavage, see Yang et al, Mol Cell Biol 29 (2009). Another protein in this complex is the histone stem-loop binding protein DDB_G0277383, which is threefold upregulated in the rblA mutant.

The high overexpression factor of EriA, comparable to that of replication-specific DNA polymerases, suggests that this may be the main function of this gene in Dictyostelium.

Harry MacWilliams, September 2009

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