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DDB G0275983 is, beyond reasonable doubt, the Dictyostelium ortholog of cdc6, long known to be a critical member of the DNA pre-replication complex, and more recently implicated in control of mitosis (see Boronat and Campbell, Cell Cycle 7 (2008). The role of DDB G0275983 in Dicty cell cycle progression is supported by its eightfold overexpression in a Dicty strain lacking the retinoblastoma-like gene, rblA (Doquang et al, in preparation). Most genes involved in DNA replication and mitosis are overexpressed in this strain.

Harry MacWilliams, April 2009

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