DDB_G0290799 - dictyBase/community-annotations GitHub Wiki

DDB G0290799 is highly conserved throughout the eukaryotes. It contains a YjeF domain, which in other systems has been implicated in the regulation of RNA stability, specifically of genes involved in eukaryotic cell cycle regulation, see Anantharaman and Aravind, BMC Genomics 5:45 (2004). A budding yeast homolog, YKL151C, is expressed at M/G1 after temperature-sensitive cdc28 synchronization.

DDB G0290799 is 8-fold overexpressed in a Dicty strain lacking the retinoblastoma-like gene rblA (Doquang et al, in preparation). Most genes whose products are necessary for DNA replication, centrosome duplication and mitosis are overexpressed by similar factors in this strain. This supports the idea that DDB G0290799 is involved in Dicty cell cycle progression.

Harry MacWilliams, May 2009

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