DDB_G0289341 - dictyBase/community-annotations GitHub Wiki

DDB_G0289341 is similar (best Blast hit, both ways) to nse2, an E3 sumo protein ligase which acts in a complex with SMC5 and SMC6 in homologous recombination and telomere maintenance, see Murray and Carr, Nature Reviews Molecular Cell Biology 9(2008). Both of these processes are associated with chromosomal replication. DDB_G0289341 is overexpressed threefold in a Dicty strain in which the retinoblastoma-like gene rblA is disrupted (Doquang et al, in preparation). Most genes associated with S-phase or mitosis are overexpressed in this strain, including other genes probably involved in homologous recombination, such as rfaA1, recA, rad51, rad51c, rad52 and rad54, and telomere maintenance, including DDB_G0287899 (rif1), DDB_G0293070 (TEP1), DDB_G0268660 (NAM7).

Harry MacWilliams, September 2009

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