DDB_G0274419 - dictyBase/community-annotations GitHub Wiki

DDB_G0274419 appears to encode a DNA polymerase with closest affinities to pol I of bacteria (the Kornberg polymerase). This is a low-processivity polymerase thought to function in DNA repair. DDB_G0274419 is only marginally (2x) overexpressed in a Dicty strain in which the retinoblastoma-like gene rblA has been disrupted (Doquang et al, in preparation). DNA polymerases associated with replication show overexpression factors of 5- to 14-fold in this strain, as do several genes associated with replication-coupled repair, while most genes associated with replication-independent repair pathways show overexpression factors of 2 or less. This suggests that DDB_G0274419 acts in replication-uncoupled DNA repair.

Harry MacWilliams, September 2009

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