DDB_G0269684 - dictyBase/community-annotations GitHub Wiki

DDB_G0269684 is weakly similar to tome-1 (Trigger of Mitotic Entry), also known as cdcA3, a gene first characterized in the mouse, which is also found throughout the metazoans; budding yeast also contains a related gene, YJL201W. Tome-1 is an F-box protein which associates with the E3 ubiquitin ligase skp-1 and mediates the destruction of the cdk inhibitory kinase wee1 Ayad et al, Cell 113, 101-13 (2003). The yeast gene is weakly but clearly cell-cycle regulated, but the expression peak is not in G2, as one might expect for a mitotic protein, but in G1.

DDB_G0269684 is overexpressed fourfold in a Dicty strain lacking the retinoblastoma-like gene, rblA (Doquang et al, in preparation). Most genes with known function in DNA replication, centrosome duplication and mitosis are overexpressed in this strain. This suggests that DDB G0269684 has a role in Dictyostelium cell cycle progression.

Harry MacWilliams, May 2009

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