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Yes. Just use the configure option --enable-darwin-x11. Note that you will need to build all packages (Coin and SoQt/SoXt) using this flag - using SoXt with the "standard" Coin won't work.

You might also want to disable frameworks and do a UNIX-style .dylib install instead: --without-framework.

So e.g. if you want to build both Coin and SoXt, you would configure them as

Coin/configure --enable-darwin-x11 --without-framework
SoXt/configure --enable-darwin-x11