LyxBuilder - ajf58/scons GitHub Wiki
Teaching PDF to understand .lyx files
Note that this builder has been added to the SCons "contrib" repo at https://bitbucket.org/scons/scons-contrib , as of 2016-12-07! Get your latest copy from there...
Usage
#!python
env = Environment(tools=['default','pdftex','pdflatex','lyx'])
env.PDF(source='test.lyx')