Week4 Feb 5 Feb 11 - WangXueqing007/Master_Thesis GitHub Wiki
Feb 05:
Good insights from group meetings up till now:
Do replicates (repeated experiments).
Use controls to make your results trustable.
Feb 9:
GLIC Meeting:
Show the results: Lindane-4npq/4hfi, PFL-5muo. 4hfi at ~2', 4npq in the upper part, while in 5muo it is everywhere...
Reba: 4npq is more used.
Reba: Remove everything other than protein in the receptor structure--could explain a bit about the weird docking poses of PFL? (The crystallization state in detergent is unnatural...)
Reduce the grid size?
Lucie: Since docking is not very reliable anyways...Just go direct into my own project. Control groups should be enough! (for a master thesis)
To do:
A brief wrap-up is favorable?
Need to figure out why the bash line script works weird...
What is next?
Feb 9:
From the GLIC meeting:
The results (shown in google drive): lindane-4npq/4hfi correspond to the previous docking results. PFL-5muo doesn't (PFL everywhere).
Reba: restrain the docking grid to the original ligand area?
Reba: the detergent interferes--remove them; this may interpret a bit about the available docking positions?
Lucie: docking result is not very reliable anyways, and the control groups are enough (for a master thesis); go directly into the "real" project?
Feb 10 Sat:
To-do list:
Get more inspiration from papers. Focus on the method part--how do they do docking?
Solve the existed technical problems (reported in google drive study notes)
A good arrangement of folders (Macbook, hard drive & remote) is needed! ! ! (Now a bit messy and confusing)