Terminate an EC2 instance - VertebrateResequencing/vr-pipe GitHub Wiki
Running EC2 instances cost you money (they are charged by the hour), even if you're not really using them, so you should terminate them when you no longer need them. VRPipe, if configured to use its ec2 or sge_ec2 schedulers will handle instance launching and termination for you automatically.
If, however, you've manually launched an instance, you can terminate it by going to your EC2 Management Console, selecting the desired instance, opening the Actions menu, and choosing "Terminate".
Note that, depending on how the instance was configured when launched, you will likely lose any data stored on its root drive. Typically, however, you should be storing user data on a shared filesystem, so this should not be a problem.