MetaboAnalyst

Version: 4.0

Website

http://www.metaboanalyst.ca/

Description

MetaboAnalyst 3.0 is a web server. It contains eight independent modules for analysis: statistical analysis, enrichment analysis, pathway analysis, time series analysis/ two factor design, power analysis, biomarker analysis, integrated pathway analysis and other utilities (data conversion, batch effects correction and lipidomic analysis). For statistical analysis PCA, PLS-DA, OPLS-DA, sPLS-DA, t-tests, ANOVA, heatmaps, dendrograms, random forests and SVM are supplied. Metabolite set enrichment analysis (MSEA) is performed in the enrichment module. Pathway analysis integrates enrichment analysis with pathway topology analysis. It also includes visualisation for the metabolic pathways for 21 model organisms, totalling ~1600 pathways. The time series analysis/ two factor design module includes ANOVA-simultaneous component analysis (ASCA), two-way ANOVA, and empirical Bayes time-series analysis. Users can calculate the minimum number of samples required for sufficient power for statistical analysis using the power analysis module. Biomarker analysis provides ROC curve based biomarker analyses. Metabolomic and gene expression data can be combined in the integrated pathway analysis module. Only basic support is provided for the processing of raw data. It can also be downloaded and installed locally.

Functionality

• Workflow

Instrument Data Type

• MS/GC-MS
• MS/LC-MS
• NMR

Approaches

Computer Skills

Basic

Software Type

Web Based

Interface

Web User Interface

Operating System (OS)

• Unix/Linux
• Mac OS
• Windows

Language

Java, R

Dependencies

N/A

Input Formats - Open

mzData, mzXML, netCDF, Peaklist - csv, txt

Input Formats - Proprietary

N/A

Published

2009

Last Updated

2018

License

Paper

http://www.ncbi.nlm.nih.gov/pubmed/25897128

PMID

25897128