MetSizeR

Version: 1.1

Website

https://cran.r-project.org/web/packages/MetSizeR/index.html

Description

MetSizeR is a CRAN package that provides a GUI for estimating the sample size required for targeted and NMR metabolomics experiments, even when pilot studies are not available. When a pilot study is not available, pseudo-metabolomic data is simulated with a statistical model. The statistical model used depends on which of probabilistic principal components analysis (PPCA), probabilistic principal components and covariates analysis (PPCCA) or dynamic probabilistic principal components analysis (DPPCA) the user intends to use for analysis of the studies data. The user must specify the desired FDR and the optimal sample size is the one with this FDR. When there is a pilot study available the Test Statistic is estimated using a permutation technique, maintaining between subject variability and noise level.

Functionality

• Other Tools/Experimental Design

Instrument Data Type

• NMR
• MS

Approaches

• Targeted

Computer Skills

Medium

Software Type

R Package

Interface

Graphical user interface

Operating System (OS)

• Unix/Linux
• Mac OS
• Windows

Language

R

Dependencies

mvtnorm, MetabolAnalyze, cairoDevice, gWidgets, gWidgetsRGtk2

Input Formats - Open

.txt/ none

Input Formats - Proprietary

N/A

Published

2014

Last Updated

2015

License

GPL-2 | GPL-3

Paper

http://www.ncbi.nlm.nih.gov/pubmed/24261687

PMID

24261687