MetPA

- Deprecated

Website

http://metpa.metabolomics.ca/MetPA/faces/Home.jsp

Description

Metabolomics Pathway Analysis (MetPA) offers both overrepresentation analysis and GSEA-based approaches, with algorithms offered including: Fishers' eaxct test, hypergeometric test, global test and GlobalAncova. Relative betweeness centrality and out degree centrality measures are used to assign compound importance. Pathway impact is calculated by the sum of the importance measures of the matched metabolites normalised by the sum of the importance measures of all the metabolites in the pathway. Univariate analysis (one-way ANOVA, t-test and linear regression) can then be used to statistically analyse the importance of individual metabolites in phenotypes. Pathways are from KEGG. As of 2011 MetPA is part of MetaboAnalyst.

Functionality

• Pathway Analysis/Metabolite Set Enrichment Analysis

Instrument Data Type

Approaches

Computer Skills

Basic

Software Type

• Web App

Interface

• Web user interface

Operating System (OS)

• Unix/Linux
• Mac OS
• Windows

Language

R, Java

Dependencies

N/A

Input Formats - Open

List of compound IDs/ & concentrations

Input Formats - Proprietary

N/A

Published

2010

Last Updated

2010

License

Paper

http://www.ncbi.nlm.nih.gov/pubmed/20628077

PMID

20628077