MPEA

Version: 1

Website

http://ekhidna.biocenter.helsinki.fi/poxo/mpea/

Description

Metabolite Pathway Enrichment Analysis (MPEA) is designed for GC-MS metabolite enrichment analysis. It tests whether metabolites involved in a predefined pathway are at the top or bottom of a rank query compound list. As input either a pre-annotated list of compounds or GC-MS data with mass spectral tags (MSTs) must be used. MSTs are identified from the golm metabolome database. There are two modes of enrichment analysis: single set and iterative, with single set being used for unranked lists and iterative used for lists ranked by e.g. t-tests. A entity relationship matrix is created to resolve the many-to-many relationships between the query compounds and those in the pathway. The statistical significance is tested using the hypergeometric distribution. KEGG and SMPDB are used to obtain the pathways.

Functionality

• Pathway Analysis/ Metabolite Set Enrichment Analysis

Instrument Data Type

Approaches

Computer Skills

Basic

Software Type

• Web App

Interface

• Web user interface

Operating System (OS)

• Unix/Linux
• Mac OS
• Windows

Language

Dependencies

N/A

Input Formats - Open

List of compound IDs/ MSTs

Input Formats - Proprietary

N/A

Published

2010

Last Updated

2010

License

Paper

http://www.ncbi.nlm.nih.gov/pubmed/21551139

PMID

21551139