Integrated Interactome System

Version: 1.0.2

Website

http://bioinfo03.ibi.unicamp.br/lnbio/IIS2/

Description

Integrated Interactome System (IIS) is a web-based tool that allows integration of different bioinformatics software for the analysis of multi-omics datasets. It designed primarily for the entire processing pipeline of yeast two-hybrid system screens (Y2H), with modules available for processing, annotation, analysis and visualisation. It supports the analysis of preprocessed metabolomics data, uploaded as a peaklist with either HMDB, YMDB or ECMD IDs. Proteins/genes can be searched against 9 databases for identification, however this is not possible for metabolomics data. A database of interactions (Global Protein-Metabolite-Gene-Drug Interaction Database (GPMCDID)) can be searched to build networks. This database is constructed from nine databases including HMDB, YMDB, ECMDB and DrugBank. Networks can be built and visualised in cytoscape. KEGG database enrichment analysis can be performed.

Functionality

• Pathway Analysis

Instrument Data Type

Approaches

• Multi-omics
• Metabolomics
• Proteomics
• Transcriptomics

Computer Skills

Web App

Software Type

• Web Based

Interface

• Web User Interface

Operating System (OS)

• Unix/Linux
• Mac OS
• Windows

Language

JavaScript, JSON, PHP

Dependencies

N/A

Input Formats - Open

txt Peaklist

Input Formats - Proprietary

Published

2014

Last Updated

2014

License

Paper

https://www.ncbi.nlm.nih.gov/pubmed/24949626

PMID

24949626