Synthetic Design - OpenSourceTB/OSTB_Series_1 GitHub Wiki

The core aspects of the synthetic chemistry have been published: PLoS ONE paper describing Phase 1 of the Spiro series (mostly organic chemistry) conducted at The University of Sydney: K. A. Badiola, D. H. Quan, D. H., J. A. Triccas, M. H. Todd, Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science, PLoS ONE 2014, 9 (12), e111782. Includes Supporting Info, raw data files and a browseable snapshot of the relevant lab notebook.

Further aspects relevant to the synthesis of other analogs will be described in a paper that has been submitted for publication.