Sources of Data - OpenSourceTB/OSTB_Series_1 GitHub Wiki

Online Project Resources

Master List of all OSTB compounds

Jessica Baiget's Lab Notebook for Her Sydney Work (Short version: https://tinyurl.com/OSTB-Jessica-Baiget)

Javier Osende's Lab Notebook

Papers

Identification of Series 1 hits: Fueling Open-source Drug Discovery: 177 Small-molecule Leads Against Tuberculosis, L. Ballell, R. H. Bates, R. J. Young, D. Alvarez-Gomez, E. Alvarez-Ruiz, et al. ChemMedChem 2013, 8:313–321.

PLoS ONE paper describing Phase 1 of the Spiro series (mostly organic chemistry) conducted at The University of Sydney: K. A. Badiola, D. H. Quan, D. H., J. A. Triccas, M. H. Todd, Efficient Synthesis and Anti-Tubercular Activity of a Series of Spirocycles: An Exercise in Open Science, PLoS ONE 2014, 9 (12), e111782. Includes Supporting Info, raw data files and a browseable snapshot of the relevant lab notebook. The back story of how this paper was published may be read on Mat Todd's blog.

Article on mechanism of action: Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3, M. J. Remuiñán, E. Pérez-Herrán, J. Rullás, C. Alemparte, M. Martínez-Hoyos, D. J. Dow, et al. PLoS ONE 2013, 8 (4), e60933

Theses

Javier Osende's Thesis (University of Sydney)