Modification of South - OpenSourceTB/OSTB_Series_1 GitHub Wiki

Exploration of the South (the N-substituent) was performed by Katrina Badiola at The University of Sydney, with the potency data being obtained by A/Prof Jamie Triccas and Gayathri Nagalingam at the same university. This was OSTB Series 1 Project 1.

One compound (OSTBS4, TCMDC-142379) had been tested previously by GSK (CHEMBL2098175), and one has been made previously for a non-TB project.

A paper describing this part of the OSTB project was published. Further variation in this region was carried out in Sydney in 2014 by Jessica Baiget as part of a collaboration with OSTB ("Project 3" in this series), generating the following data. The lower portion of the molecule derives from Open Source Malaria's First Series.

A forthcoming paper describes further variation in this region by GSK as part of an internal research project.