Mechanism of Action - OpenSourceTB/OSTB_Series_1 GitHub Wiki

It was reported that the mechanism of action was ''via'' the mycolic acid transporter Mmpl3, the target of multiple recently-identified chemotypes (e.g. indoleamides) (Review). A more recent paper suggests that Mmpl3 is not the target of these chemotypes, but rather that these compounds act to dissipate transmembrane proton gradients. This brings into question whether Mmpl3 is the target of the Spiros series. There is also the question of why so many compounds are discovered that appear to hit membrane targets, with the likely fault being high logP.