PostEra COVID Moonshot - OpenSourceSarsCoV2/LivingResourceReview GitHub Wiki

Short description

PostEra AI is a for-profit startup company that specialises in integrating molecular design with chemical synthesis. As a result of the coronavirus pandemic, and stemming from the data produced by the Diamond Light Source, PostEra have collaborated with academic institutions and industry around the world, while adopting open science principles, to design new inhibitors of the SARS-CoV-2 main protease. This global collaboration effort allows anyone to suggest new inhibitors based on the initial Diamond fragment hits. Following this, the most attractive compounds will be identified using machine learning algorithms, synthesised by a contract synthesis company and evaluated in inhibition assays (fluorescence and RapidFire mass spectrometry) against the SARS-CoV-2 main protease in labs around the world. Importantly, all stages of this process will be made publicly available. To date [12 August 2020], over 7000 compounds have been suggested by the community with over 1000 being ordered commercially. Additionally, around 500 compounds have been synthesised and assayed.

Links and references

COVID Moonshot: https://postera.ai/covid