Activate Essential Files

First, run the program named Essentials Files from Mod Organizer 2. This step will add the required files for SKSE, Engine Fixes, DLL loader and other essential files that cannot be handled by MO2.

Then Click "OK" if you get a message saying something about Failed to check for update. This is ok.

Then navigate to the Presets menu by pressing the symbol in the top left (the three lines). The menu should look like this:

Now you will need to toggle on some options:

If this is your first time install, and if any options are toggled on, then toggle everything off before you continue to the next steps.

1. You must activate the the "Essential Files" option. All others are optional.
2. SteamVR - This is on by default, necessary if you run the game via SteamVR.
3. opencompoisite - This can replace SteamVR and will give Oculus users a strong performance boost.
4. openvr_fsr - AMD sharpener, not compatible with opencomposite, mixed reviews. Test at your own risk.
5. VR Performanc Kit - Performance-oriented collection of mods for VR games
6. Real Virtual Magic - Only for users with a Muse2 meditation device. Lets you use your real mental powers to enhance magic play in Skyrim.
7. Once you are done, make sure you press Sync, just to make sure everything got added successfully.