Patch Troubleshooting - KravitzLab/KreedLabWiki GitHub Wiki
A page for tips and tricks when the patch rig, etc. just will not cooperate
Problem: No matter what you do (change both grounds, check other internals, rechloride the grounds, etc) the pipette offset is massive.
Try restarting everything. And I don't mean "restart the computer", I mean turn it off and unplug the multiclamp digitizer.