Meeting 4 - GeorgeIniatis/Blood_Brain_Barrier_Drug_Prediction GitHub Wiki

Meeting Minutes

This meeting focused on Q/A and brainstorming

Q: General feedback about the project so far. Anything to improve?

• The project is going really well and is on track

Q: How to use Automated Google Searches

• Use requests to get the html. Note: Use a header to make it look like we are using a browser
• Regular expressions to look for our search

Q: Can we actually trust the results we get from Google Searches:

• We could look at the sources

Brainstorming:

• Is there a way to infer the side effects for the compounds and drugs that currently don't have any associated with them?
  • Or do we just treat their side effects as not available?
• Can we figure out the side effects that have the most impact on BBB
• How are the models going to be evaluated?
  • Cross validation
  • Y Scrambling
• Dissertation Ideas
  • Logically describe and explain clearly how the models were created, validated and evaluated
  • Class imbalance. Can we actually know the real distribution of compounds and drugs that pass or not the BBB

Action Plan

• Use Automated Google Searches to gather more compounds and drugs for the dataset
• Extract indicators from SIDER database and add them to the dataset