Protect your profiles (*.binding files) - DCS-Skunkworks/DCSFlightpanels GitHub Wiki
Keep backups
You need to keep backup of your profiles. Bugs, new and old can corrupt a profile and especially the Streamdeck configuration is vulnerable since it contains much more detailed information.
New release
It is a good idea to copy your profiles to a backup folder before using a new release. In case of corruption you can then go back a version and use the backed up profiles.