please read everything below so at least it will be in the back of your head when you play.

Ingame, Press F11 for a list of Key Bindings !!!

There are other optional settings you can enable in the 'MCM Recorder' mod.

I recommend playing as the dragonborn in the NEFARAM START MCM, because a lot of NPCs and Quests will still reference you as dragonborn, unless you can make some RP about it (Some of the new followers can 'act' as Dragonborn as you will discover... ).

You can modify your body type with OBody (Press F10). Or others people's bodies man or woman if you aim at them with your crosshair.

Press G for the Survival Wheel, with tons of useful actions to do. The 'Status' one especially.

In the Sexlab MCM you can set the sexual orientation of your character.

All debug spells are located in your Powers Keyring Power.

The Notification Log MCM is very useful to read what you might've missed ingame.

You can hide quests you dont want to do with Hide your quests.

Press Shift while interacting with stuff to access more options.

To play a Futa character, you need to go into T.N.G. MCM and configure it as you want.

I removed most weird conditions like books to craft armors from mods or chests with the armors placed in the world : you usually need just the right smithing perk and sometimes a quest completed (Stormcloak gear if you join the stormcloaks, Brotherhood bandoliers if you join them etc...), at merchants, or worn by NPCs. Here is the full list of changes.

If you have some devices you can't take off talk to blacksmiths, fences, guards or jailmasters in city jails.

Feel free to edit the MCMs of mods, most do not pose issues apart from gameplay and balance changes, Like Sexlab Survival, by default I disabled something like 80% of the mod but you can reenable them, but be warned it becomes hardcore very quickly. However modify them at your own risk, for example if you reenable decapitations in Violens you will crash :)

Save often but not too much : avoid saving during combat or just before you load through a door. F5 now does a full save.

To change the position of your weapons (like if you want your sword on your back or dagger on the hip), press Shift+Backspace.

You can change ENB with the included ENB Organizer.

You can set CPU affinity for the game, which improves performance a bit, by clicking here in MO2 :

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Resources

Keyboard layout : Also middle mouse to change camera shoulder, Mouse4 for blocking even while dual wielding or unarmed, Mouse5 to toggle aimlock:

HUD layout information :