Opening CellProfiler on Mac OS 10.15.7 - CellProfiler/CellProfiler GitHub Wiki

Some users have reported experiencing issues when opening CellProfiler since updating to macOS 10.15.7. While we are still investigating the problem, we have found a couple of workarounds to successfully open CellProfiler, which we share below.

Most of the problems that we have seen occur when CellProfiler is opened from the /Applications folder in the Finder. If you are experiencing such problems, we recommend the following step-by-step installation procedure:

  1. Download CellProfiler-macOS-X.XX.zip from the Releases page.
  2. Move your CellProfiler-macOS-X.XX.zip directly from ~/Downloads to /Applications, without extracting the contents.
  3. Extract the contents of CellProfiler-macOS-X.XX.zip in the /Applications folder.
  4. Open the extracted CellProfiler app.

Alternatively, you can try the following:

  1. Download the CellProfiler-macOS-X.XX.zip from the Releases page.
  2. Download the CellProfiler-macOS-X.XX.zip to your ~/Downloads folder.
  3. Extract the CellProfiler app into your ~/Downloads folder.
  4. Move the CellProfiler app into the /Applications folder.
  5. Right-click on the app, click “Rename” and rename CellProfiler to CellProfiler2.
  6. Try opening CellProfiler2.

If these workarounds above do not work, or if you are having trouble opening CellProfiler from your ~/Documents or ~/Downloads folder, please file an issue on the issue tracker on Github, or report to the CellProfiler forum.

Note: when trying to open CellProfiler, a dialog window stating that "CellProfiler cannot be opened because the developer cannot be verified" may show. To open CellProfiler, right-click on the app and click "Open". Another dialog window appear and will give you the option to "Open" the application.