---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
nocite: |
  @zhangGeneticHeterogeneityDiffuse2013, 
---
[[_TOC_]]


## Relevance tier by entity

[[include:tables/table1_SMEK1.md]]

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |  NA         |
|DLBCL |Schmitz cohort|1.91         |
|DLBCL |Reddy cohort  |0.90         |
|DLBCL |Chapuy cohort |2.99         |

## Mutation pattern and selective pressure estimates

|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
|:------:|:----:|:---------------------:|:----------------:|:----------------:|
|BL    |No  |No                   |0.000           | 5.691          |
|DLBCL |No  |No                   |1.264           | 0.000          |
|FL    |No  |No                   |9.566           |58.730          |


[[include:tables/browser_SMEK1.md]]

## Expression
![](images/gene_expression/SMEK1_by_pathology.svg)
<!-- ORIGIN: chapuyMolecularSubtypesDiffuse2018b -->
<!-- DLBCL: chapuyMolecularSubtypesDiffuse2018b -->

[[include:tables/mermaid_SMEK1.md]]

## References