---
bibliography: 'morinlab.bib'
csl: 'NLM.csl'
link-citations: true
nocite: |
  @hubschmannMutationalMechanismsShaping2021, 
---
[[_TOC_]]


## Overview

Mutations in this gene were first described in DLBCL in 2021 by Hübschmann et al.[@hubschmannMutationalMechanismsShaping2021]


## Relevance tier by entity

[[include:tables/table1_LRP12.md]]

## Mutation incidence in large patient cohorts (GAMBL reanalysis)

|Entity|source        |frequency (%)|
|:------:|:--------------:|:-------------:|
|DLBCL |GAMBL genomes |2.49         |
|DLBCL |Schmitz cohort|2.34         |
|DLBCL |Reddy cohort  |2.40         |
|DLBCL |Chapuy cohort |2.56         |

## Mutation pattern and selective pressure estimates

[[include:tables/dnds_LRP12.md]]




[[include:tables/browser_LRP12.md]]

## Expression
![](images/gene_expression/LRP12_by_pathology.svg)

## All Mutations

[SP194077](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP194077.html)
[SP59460](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP59460.html)
[SP193258](https://www.bcgsc.ca/downloads/morinlab/GAMBL/MALY/SP193258.html)

[[include:tables/mermaid_LRP12.md]]

## References


<!-- ORIGIN: hubschmannMutationalMechanismsShaping2021b -->
<!-- DLBCL: hubschmannMutationalMechanismsShaping2021b -->