The EU version is almost a complete super set of the US version. If you are flying in the US, you might still want to use the EU version as it contains a lot of new features and bug fixes. The only thing that is missing is support for OLED displays and RaspberryPis that are older than the 3B. For use in the US, you will want to change the configuration on the web interface:
default setup for Europe Edition (Hardware Settings):
setup for US:
Note: this disables OGN traffic reception (rarely used in US) but enables 978 UAT reception instead
As of version eu026, we also provide a ready-to-use pre-configured image for US. Typically, it is also uploaded to the cyoung/stratux releases page, but usually that comes a bit later. Note that this version is just the EU version with the above settings changed.