Wineskin is powered by Wine, you may find pointers regarding configuration,
dependencies and overrides necessary for a working program at :

• WineHQ DB
• Lutris DB: look at install scripts
• ProtonDB: look at comments, look at issues in GitHub

To enable DXVK, use Winetricks and install one of the provided verbs.
This will copy d3d10, d3d11 and dxgi dlls to your wrapper and edit
its registry to override Wine defaults. On Apple SoC M1, it crashes often.
Don't worry, return to Winetricks and try again.

Most recent games will need you to add, through Winetricks:
vcrun2019, d3dx10_43, d3dx11_43, d3dcompiler_43 or 46 or 47.

Some games use Xaudio. Faudio is a good open reimplementation if you need an alternative.

With the Custom EXE Creator (in Advanced Tools), and Aliases, you can install multiple programs/games
inside a single wrapper. Aliases allow you to make shortcuts outside the wrapper.
It is a better practice to tailor a wrapper for a single program.

You can set /drive_c/windows/explorer.exe as the default executable ; after what it is easy to manage/view
your windows filesystem, e.g. launch custom tools directly like mod managers, setup executables etc.

Try Explorer++
Try Windows File Manager